Metastatic Prostate Cancer

Hormonal Therapy

Hormonal therapy treatment metastatic prostate cancer

Hormonal therapy is a treatment option for metastatic prostate cancer. It aims to slow down the growth of the tumours.

The growth of prostate cancer cells is dependent on male sex hormones called androgensTestosterone is the most important androgen. Androgens are mainly produced in the testicles.

Hormonal therapy either stops the production of androgens, or blocks their action. This is known as castration. Another name for hormonal therapy is androgen deprivation therapy (ADT). It can be performed surgically or with drug treatment.

In surgical hormonal therapy both testicles are removed in a procedure called bilateral orchiectomy. This procedure can be performed under local anaesthesia. Hormonal drug therapy to stop the production of androgens includes LHRH agonists and LHRH antagonists. These drugs are available as pills or as depot injections right under the skin or into the muscle. Anti-androgens are drugs that block the action of androgens. They come as a pill.

The effect of hormonal therapy will not last and leads to castration-resistant prostate cancer.

To delay castration resistance, your doctor may recommend to pause the hormonal drug therapy. This is called intermittent hormonal therapy. During the treatment pause, you will have to visit your doctor every 1-3 months. The doctor will monitor the level of prostate-specific antigen (PSA) in your blood.

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Read more about hormonal therapy for metastatic prostate cancer and what to expect during treatment.