Other focal and specialised treatments for prostate cancer

Focal or ablative treatments aim to destroy cancer tissue inside the prostate using heat or freezing.

Unlike surgery or radiotherapy, these treatments do not always treat the whole prostate. In some cases, they target the entire gland, but in others they focus only on the area where the cancer is located.

According to current European guidelines, these treatments are:

• Not considered standard treatment for most men
• Usually offered only in specialised centres
• Often provided within clinical trials or research studies

They are generally considered for selected men with localised (high-intermediary risk) prostate cancer.

They are not recommended for high-risk or locally advanced prostate cancer outside clinical trials.

If you are considering HIFU or cryotherapy, it is important to discuss:

• Whether your cancer stage and risk group make you suitable
• The long-term evidence for cancer control
• Possible side effects
• Whether the treatment is part of a clinical study

Your doctor can help you understand whether a standard treatment or a specialised approach is most appropriate for you.

This chapter contains general information about focal and specialised treatments for prostate cancer. It is not a substitute for professional medical advice or treatment. Always consult your doctor or healthcare provider for guidance on your individual medical situation.

The creation of this chapter was funded by Ferring Pharmaceuticals. Its content has been independently developed and approved by the EAU Patient Office.

Last updated: February 2026

Reviewed by: 

• Dr. Nikolaos Grivas (Guideline Panel on Prostate Cancer)
• Mr. Eamonn Rogers (Patient Office Chairman)
• Dr. Erik Briers (Patient Office EPAG)