Orchidectomy for testicular cancer

How will my testosterone level be affected after an orchidectomy?

If one testicle is removed, your body will usually still produce enough testosterone as long as the other testicle is healthy. However, if you have had or are having chemotherapy, your testosterone levels might drop temporarily. The good news is that they usually go back to normal after treatment, but this can take up to a year.

If you have both testicles removed (bilateral orchidectomy), your body will have very little testosterone, and you will need testosterone replacement therapy to stay healthy.

How will I know if my testosterone is low?

You might have low testosterone if you notice symptoms like:

• Tiredness
• Low mood
• Confusion and feeling emotional
• Hot flushes
• Weight gain
• Loss of muscle
• Loss of or difficulty in getting normal erections on waking up in the morning
• Low sex drive (loss of libido)
• Trouble getting or keeping an erection
• Breast swelling (gynaecomastia)

Possible long-term symptoms of low testosterone include:

• Thinning of the bones (osteoporosis)
• Higher risk of heart problems

A blood test to check testosterone levels.

Testosterone levels can be checked by a blood test. They are at their highest early in the morning, and this is when the blood test should be done. If you have symptoms of low testosterone, your doctor may suggest trying testosterone therapy to see if it helps.

This chapter contains general information about orchidectomy for testicular cancer. It is not a substitute for professional medical advice or treatment. Always consult your doctor or healthcare provider for guidance on your individual medical situation.

Last updated: July 2025

Reviewed by:

• Mr. Robert Cornes (Patient Office EPAG)
• Dr. Walter Cazzaniga (YAU Working Group on Testicular Cancer)