Locally-advanced Prostate Cancer

Hormonal therapy locally-advanced prostate cancer

Hormonal therapy locally-advanced prostate cancer

Hormonal therapy is a treatment option for locally-advanced prostate cancer. It aims to stop the growth of the tumour.

The growth of prostate cancer cells is dependent on male sex hormones called androgensTestosterone is the most important androgen. Androgens are mainly produced in the testicles. Hormonal therapy either stops the production or blocks the action of androgens. This is known as castration.

Another name for hormonal therapy is androgen deprivation therapy (ADT). It can be performed surgically or with drug treatment. In surgical therapy, both testicles are removed in a procedure called bilateral orchiectomy. The surgery is generally done under local anaesthesia. Drug therapy to stop the production of androgens includes LHRH agonists and LHRH antagonists. These drugs are available as depot injections right under the skin or into the muscle. Anti-androgens are drugs that block the action of androgens. They come as a pill. All of these therapies cause castration.

Castration has physical and emotional consequences. The most common are hot flushes, lower sex drive, and erectile dysfunction. The effects of surgical castration are permanent. In chemical castration, some of the symptoms may disappear after the treatment. Do not hesitate to discuss any concerns with your doctor.

In locally-advanced prostate cancer the standard treatment to cure the disease is hormonal therapy in combination with radiation therapy.

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Read more about different types of hormonal therapy and what to expect during and after the treatment.